Eurycomanone was inactive against murine lymphocytic leukemia (P-388) however was considerably lively in opposition to the human cell lines examined. Two extra isolates, the beta-carboline alkaloids beta-carboline-1-propionic acid and 7-methoxy-beta-carboline-1-propionic acid, were not considerably energetic with these cultured cells. However, compounds 5 and 7 were found to show significant antimalarial exercise as judged by research carried out with cultured Plasmodium falciparum strains. The buildings of the novel compounds 2-four and seven had been established by spectral and chemical strategies. Antioxidant activity and hepatoprotective potential of Phyllanthus niruri, a broadly used medicinal plant, were investigated.
However, dichloromethane and ethyl acetate fractions might suppress Staphylococcus aureus progress with IDZs of two.seventy two±0.30 mm and 4.89±0.72 mm, respectively. Further analysis with TLC-bioautography on dichloromethane fraction confirmed three compounds with Rf values of zero.88, zero.84, and zero.78 have antibacterial exercise. Elderberry is an historical herbal medicine usually produced from the cooked fruit of the Sambucus nigra plant. It has long been used to relieve complications, nerve pain, toothaches, colds, viral infections, and constipation .
Antioxidant compounds have been recognized by Thin Layer Chromatography (TLC)–autographic assay using zero.02% 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution. Antioxidant activity was analyzed using DPPH methodology, whereas antibacterial activity was evaluated using TLC-bioautographic and agar disc diffusion methods. The outcomes confirmed that antioxidant compounds have been present in all fractions, with the best chemical constituents was in dichloromethane fraction. The antioxidant activity of dichloromethane fraction was the very best of all fractions with IC50 value of 95.83±19.64 µg/mL, whereas ethyl acetate fraction was the bottom activity with IC50 worth of 174.56±21.ninety three µg/mL. The antibacterial assay indicated that water fraction might inhibit Escherichia coli growth with inhibition diameter zone (IDZ) of 2.36±1.11 mm.
The traditional elements of Indonesia are influenced by many countries. This is due to Indonesian geographical and historic connections with some countries such as the Malay Peninsula, India, Middle East, China, and Europe. Food texture is a main attribute of Indonesian foods because it significantly contributes to the taste and overall traits of meals.
Only 14-deoxyandrographolide and 14-deoxy-11,12-didehydroandrographolide exhibited cytotoxic actions (primarily based on EC50 values), but this was limited to the T-47D cell line (EC50 values of 2.eight µg/ml and 1.5 µg/ml, respectively). By bioactivity-directed fractionation, 5 cytotoxic constituents have been characterized from the roots of Eurycoma longifolia collected in Kalimantan, Indonesia. Four canthin-6-one alkaloids, particularly, 9-methoxycanthin-6-one, 9-methoxycanthin-6-one-N-oxide, 9-hydroxycanthin-6-one, and 9-hydroxycanthin-6-one-N-oxide, and one quassinoid, eurycomanone, have been discovered to be cytotoxic rules. The canthin-6-ones 1-4 have been found to be lively with all cell lines examined aside from the KB-V1 cell line.
Methanolic and aqueous extract of leaves and fruits of P. niruri showed inhibition of membrane lipid peroxidation (LPO), scavenging of 1,1-diphenyl-2picrylhydrazyl (DPPH) radical and inhibition of reactive oxygen species (ROS) in vitro. Antioxidant activity of the extracts had been additionally demonstrable in vivo by the inhibition of the carbon tetrachloride (CCl4) – induced formation of lipid peroxides in the liver of rats by pretreatment with the extracts.
Tempeh, tahu (tofu), and kecap (soy sauce) are the frequent soy‐based protein sources consumed, they usually play important roles in Indonesian diets. The growth of jamu as functional foods has been vigorously promoted by the Indonesian authorities. This analysis was conducted to determine antioxidant and antibacterial actions of several fractions from Crescentia cujete L. The powdered stem bark of this plant was extracted by ethanol solvent and then separated by liquid-liquid extraction. The outcomes of this separation had been n-hexane, dichloromethane, ethyl acetate, and water fractions.
Indonesian diets are excessive in fiber and carbohydrates with a dietary pattern of low protein and excessive carb intake. The conventional food regimen sample has been shifted significantly toward more consumption of fats and sugar content foods as a result of demand of convenience foods, urbanization, the rise in household incomes, and changing way of life.